Document Detail

Drug exposure, pregnancy outcome and fetal and childhood development occurring in the offspring of mothers with systemic lupus erythematosus and other chronic autoimmune diseases.
MedLine Citation:
PMID:  17153855     Owner:  NLM     Status:  MEDLINE    
Most autoimmune diseases occur more commonly in females and many of these young women wish to become mothers. For pregnancy to proceed successfully immunomodulation and physiological changes preparing the reproductive system need to occur. Pregnancy occurring in a chronically ill mother who requires medications in order to maintain her own health and who may have already incurred significant organ pathology gives rise to several problems and so four questions arise: 1) What will be the effect of the pregnancy on the underlying disease? 2) What will be the effect of the disease on the outcome of pregnancy? 3) How to manage the disease, just prior to, throughout and immediately after the pregnancy? 4) The long term fetal and childhood effects of maternal disease and its management. This paper reviews the current literature pertaining to these questions in patients with systemic lupus erythematosus (SLE) and other chronic rheumatic and autoimmune diseases.
A Parke
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Lupus     Volume:  15     ISSN:  0961-2033     ISO Abbreviation:  Lupus     Publication Date:  2006  
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  808-13     Citation Subset:  IM    
Division of Rheumatology, University of Connecticut Health Center, 263 Farmington Ave, MC 5353 Farmington, CT 06030, USA.
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MeSH Terms
Adrenal Cortex Hormones / adverse effects
Antibodies, Antinuclear / drug effects
Antimalarials / adverse effects
Autoimmune Diseases* / immunology,  physiopathology,  therapy
Child Development*
Chronic Disease
Diethylstilbestrol / adverse effects
Estrogens, Non-Steroidal / adverse effects
Fetal Growth Retardation / etiology,  prevention & control
Infant, Newborn
Lupus Erythematosus, Systemic* / immunology,  physiopathology,  therapy
Pregnancy Outcome*
Xenobiotics / adverse effects
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Antibodies, Antinuclear; 0/Antimalarials; 0/Estrogens, Non-Steroidal; 0/Xenobiotics; 56-53-1/Diethylstilbestrol

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