Document Detail


Drug excretion into breast milk--overview.
MedLine Citation:
PMID:  12706545     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Breastfeeding is the optimal form of infant feeding for the first months of an infant's life, and the majority of healthy women initiate breastfeeding after the birth of their infant. However, women on medication may default to formula feeding or not taking their drug therapy for fear of exposing their infant to the medication through the breast milk. Although the majority of medications are considered to be compatible with breastfeeding, cases of significant infant toxicity exist, suggesting a case by case risk assessment to be made before the mother initiates breastfeeding or drug therapy. Unfortunately, current clinical risk assessment is often compromised by the paucity of data, as studies in breastfeeding women and their infants are ethically difficult to conduct. Circumventing the ethical constraints, approaches have been proposed to estimate drug excretion into milk from physicochemical characteristics of the drug, which diffuses through the mammary gland epithelia. However, as our understanding on drug transfer mechanisms increases, it has become abundantly clear that carrier-mediated processes are involved with excretion of a number of drugs into milk. This article provides an overview of the benefits of breastfeeding, the effect of medication use during breastfeeding on maternal decisions and infant health, and factors determining infant exposure to medication through the breast milk.
Authors:
Shinya Ito; Amy Lee
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Advanced drug delivery reviews     Volume:  55     ISSN:  0169-409X     ISO Abbreviation:  Adv. Drug Deliv. Rev.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-22     Completed Date:  2004-01-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8710523     Medline TA:  Adv Drug Deliv Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  617-27     Citation Subset:  IM    
Affiliation:
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Department of Pediatrics, 555 University Avenue, ON M5G 1X8, Toronto, Canada. shinya.ito@sickkids.ca
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MeSH Terms
Descriptor/Qualifier:
Breast Feeding / adverse effects
Female
Humans
Infant
Milk, Human / chemistry,  metabolism*,  secretion
Pharmaceutical Preparations / adverse effects,  metabolism*
Pharmacokinetics
Risk Assessment
Chemical
Reg. No./Substance:
0/Pharmaceutical Preparations

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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