Document Detail


Drug evaluation of clevidipine for acute hypertension.
MedLine Citation:
PMID:  18778189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Clevidipine is an investigational agent undergoing late-stage clinical development to evaluate its potential as a novel short-acting intravenous agent for treating acute hypertension, either in hypertensive emergencies encountered in the emergency department and intensive care units, or in the perioperative period. METHOD: Clevidipine has been evaluated in four Phase I studies, nine Phase II studies and six Phase III clinical studies. The patient populations studied include healthy volunteers, patients with essential hypertension, patients undergoing cardiac surgery, and patients presenting to the emergency department with hypertensive emergencies. Studies providing comparative data of clevidipine versus nitroglycerin, nicardipine or sodium nitroprusside are also available. OBJECTIVE: This article reviews the results of clinical studies evaluating the pharmacological properties, clinical effects and safety profiles of clevidipine in various patient populations. RESULTS/CONCLUSION: Clevidipine is an effective agent for reducing acute elevation in blood pressure in various settings, including hypertensive emergencies and perioperative hypertension with a good safety profile.
Authors:
Ika Noviawaty; Guven Uzun; Adnan I Qureshi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert opinion on pharmacotherapy     Volume:  9     ISSN:  1744-7666     ISO Abbreviation:  Expert Opin Pharmacother     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-09     Completed Date:  2008-12-29     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  100897346     Medline TA:  Expert Opin Pharmacother     Country:  England    
Other Details:
Languages:  eng     Pagination:  2519-29     Citation Subset:  IM    
Affiliation:
University of Minnesota, Zeenat Qureshi Stroke Research Center, Department of Neurology, MMC 295, 420 Delaware St S.E., Minneapolis, MN 55455, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Calcium Channel Blockers / adverse effects,  pharmacokinetics,  pharmacology,  therapeutic use*
Clinical Trials as Topic
Humans
Hypertension / drug therapy*
Pyridines / adverse effects,  pharmacokinetics,  pharmacology,  therapeutic use*
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Pyridines; 0/clevidipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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