| Drug evaluation of clevidipine for acute hypertension. | |
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MedLine Citation:
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PMID: 18778189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Clevidipine is an investigational agent undergoing late-stage clinical development to evaluate its potential as a novel short-acting intravenous agent for treating acute hypertension, either in hypertensive emergencies encountered in the emergency department and intensive care units, or in the perioperative period. METHOD: Clevidipine has been evaluated in four Phase I studies, nine Phase II studies and six Phase III clinical studies. The patient populations studied include healthy volunteers, patients with essential hypertension, patients undergoing cardiac surgery, and patients presenting to the emergency department with hypertensive emergencies. Studies providing comparative data of clevidipine versus nitroglycerin, nicardipine or sodium nitroprusside are also available. OBJECTIVE: This article reviews the results of clinical studies evaluating the pharmacological properties, clinical effects and safety profiles of clevidipine in various patient populations. RESULTS/CONCLUSION: Clevidipine is an effective agent for reducing acute elevation in blood pressure in various settings, including hypertensive emergencies and perioperative hypertension with a good safety profile. |
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Authors:
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Ika Noviawaty; Guven Uzun; Adnan I Qureshi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert opinion on pharmacotherapy Volume: 9 ISSN: 1744-7666 ISO Abbreviation: Expert Opin Pharmacother Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-09 Completed Date: 2008-12-29 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 100897346 Medline TA: Expert Opin Pharmacother Country: England |
Other Details:
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Languages: eng Pagination: 2519-29 Citation Subset: IM |
Affiliation:
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University of Minnesota, Zeenat Qureshi Stroke Research Center, Department of Neurology, MMC 295, 420 Delaware St S.E., Minneapolis, MN 55455, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Calcium Channel Blockers / adverse effects, pharmacokinetics, pharmacology, therapeutic use* Clinical Trials as Topic Humans Hypertension / drug therapy* Pyridines / adverse effects, pharmacokinetics, pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 0/Pyridines; 0/clevidipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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