| Drug-eluting stents in a patient with favism: is the aspirin administration safe? | |
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MedLine Citation:
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PMID: 18852594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe the case of a 64-year-old patient with glucose-6-phosphate dehydrogenase deficiency who was referred to our hospital because of an acute inferior myocardial infarction.Given the possible risk of acute haemolytic anaemia, aspirin was not given in the acute phase, and the patient was successfully treated by balloon angioplasty of the right coronary artery.After functional and genetic testing showing the presence of the Mediterranean mutation, known to be a class II variant, the patient received oral daily aspirin (100 mg) under strict monitoring in order to promptly detect any sign of haemolysis. After 4 days, a complex percutaneous coronary intervention with an implantation of two drug-eluting stents was successfully performed on the left coronary artery. After 3 months, the patient is free from adverse events.Glucose-6-phosphate dehydrogenase deficiency is commonly considered a contraindication to aspirin intake; however, this case shows that aspirin at low, antiplatelet dosage is well tolerated and should not be denied to patients with ischaemic heart disease and complex coronary anatomy. |
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Authors:
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Stefano Rigattieri; Pasquale Silvestri; Angelo Minucci; Cristian Di Russo; Giuseppe Ferraiuolo; Bruno Giardina; Ettore Capoluongo; Paolo Loschiavo |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of cardiovascular medicine (Hagerstown, Md.) Volume: 9 ISSN: 1558-2027 ISO Abbreviation: J Cardiovasc Med (Hagerstown) Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-14 Completed Date: 2009-01-09 Revised Date: 2009-05-28 |
Medline Journal Info:
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Nlm Unique ID: 101259752 Medline TA: J Cardiovasc Med (Hagerstown) Country: United States |
Other Details:
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Languages: eng Pagination: 1159-62 Citation Subset: IM |
Affiliation:
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U.O. Emodinamica e Cardiologia Interventistica, Italy. stefanorigattieri@yahoo.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Anemia, Hemolytic / chemically induced*, genetics Angioplasty, Transluminal, Percutaneous Coronary / adverse effects, instrumentation* Aspirin / administration & dosage, adverse effects* Coronary Angiography Drug-Eluting Stents* Favism / complications*, enzymology, genetics Glucosephosphate Dehydrogenase / genetics Humans Male Middle Aged Mutation Myocardial Infarction / complications, drug therapy, radiography, therapy* Platelet Aggregation Inhibitors / administration & dosage, adverse effects* Risk Assessment Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin; EC 1.1.1.49/Glucosephosphate Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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