Document Detail


Drug-eluting stent supported percutaneous coronary intervention for unprotected left main disease.
MedLine Citation:
PMID:  16817178     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: This study sought to determine the clinical and angiographic outcomes of unselected patients receiving drug-eluting stents for unprotected left main disease. BACKGROUND: The results of several series of percutaneous coronary intervention (PCI) for left main disease in the pre-drug-eluting stent era have arisen concerns on the safety and mid-term efficacy of PCI. METHODS: Consecutive patients with unprotected left main disease were considered eligible for drug-eluting stent supported PCI. The surgical risk score (risk of death within 1 month) of each patient was calculated according to the European System for Cardiac Operative Risk Evaluation (EuroSCORE) model. RESULTS: One-hundred and one patients with unprotected left main disease underwent PCI. The mean EuroSCORE was 19 +/- 23. Successfully left main stenting was performed in 98 patients (primary success rate 97%). The overall 1-month mortality rate was 9.9%. The 1-month mortality rate was 50% in patients with acute myocardial infarction (AMI) on presentation, and 4.5% in patients without AMI on presentation. The 1-month mortality rate of patients with a risk score <13 was 3%, while it was 21% in patients with a risk score >or=13. At 6 months, the mortality rate of the entire cohort of patients increased to 12.8%, and the one of the non-AMI patients to 7.8%. Survival rate was 86% +/- 4% (mean follow-up 295 +/- 175 days). Target vessel revascularization was performed in 14 patients (16%). The 6-month in-segment restenosis rate was 16%. CONCLUSION: Drug-eluting stent supported PCI may provide early and mid-term outcomes comparable or superior to those expected from coronary artery surgery. (c) 2006 Wiley-Liss, Inc.
Authors:
Angela Migliorini; Guia Moschi; Letizia Giurlani; Renato Valenti; Ruben Vergara; Guido Parodi; Nazario Carrabba; Emilio V Dovellini; David Antoniucci
Related Documents :
15306748 - Safety and feasibility of a novel dosing regimen of tirofiban administered in patients ...
24222218 - Relationship between dilated cardiomyopathy and the e23k and i337v polymorphisms in the...
23876528 - Understanding radiation-induced cardiovascular damage and strategies for intervention.
23591308 - Percutaneous coronary intervention without onsite cardiac surgery backup.
3280318 - Programmed electrical stimulation in hypertrophic cardiomyopathy. results in patients w...
3632138 - Electrophysiological study in the dog of the risk of cardiac toxicity of bupivacaine.
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  68     ISSN:  1522-1946     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-28     Completed Date:  2007-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  225-30     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Careggi Hospital, Florence, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Angioplasty, Transluminal, Percutaneous Coronary*
Coronary Angiography
Coronary Disease / mortality,  radiography,  therapy*
Female
Humans
Male
Proportional Hazards Models
Prospective Studies
Stents*
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Early administration of abciximab bolus in the emergency department improves angiographic outcome af...
Next Document:  The social control of behavior control: behavior modification, Individual Rights, and research ethic...