| Drug dosage in renal disease. | |
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MedLine Citation:
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PMID: 797495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Based on the well known linear relationship between the overall drug elimination rate constant and the endogenous creatinine clearance, it is shown how individual drug elimination parameters in patients with renal disease can be estimated from the patient's creatinine clearance or serum creatinine concentration. By means of a simple nomogram the elimination rate fraction is determined which describes the elimination rate of the drug as a fraction of its normal elimination rate constant. Based on the estimated elimination rate fraction the dosage regimen in the patient with renal disease is individually modified according to pharmacokinetic principles. At present the described method can be used with 45 different drugs. |
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Authors:
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L Dettli |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical pharmacokinetics Volume: 1 ISSN: 0312-5963 ISO Abbreviation: Clin Pharmacokinet Publication Date: 1976 |
Date Detail:
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Created Date: 1977-04-25 Completed Date: 1977-04-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7606849 Medline TA: Clin Pharmacokinet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 126-34 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Creatinine
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metabolism Drug Administration Schedule Humans Kidney Diseases / metabolism* Kinetics Mathematics Metabolic Clearance Rate Models, Biological Pharmaceutical Preparations / administration & dosage*, blood, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Pharmaceutical Preparations; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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