Document Detail

Drug and device therapy for patients with chronic heart failure.
MedLine Citation:
PMID:  22390803     Owner:  NLM     Status:  In-Data-Review    
Evaluation of: Grosu A, Senni M, Iacovoni A et al. Cardiac Resynchronization in Combination with β-blocker Treatment in Advanced Chronic Heart Failure (CARIBE-HF): the results of the CARIBE-HF study. Acta Cardiol. 66(5), 573-580 (2011). Untreated heart failure is a terminal illness with a poor prognosis. β-blockers are an established therapy used to reduce morbidity and mortality. Hypotension and bradycardia often hinder optimal β-blocker administration in patients with chronic heart failure. The efficacy of cardiac resynchronization therapy (CRT) in affecting favorable cardiac remodeling and reducing mortality in heart failure patients with electrical dyssynchrony has been demonstrated in landmark trials only in patients receiving optimal medical therapy. This paper demonstrates the favorable effects of CRT on cardiac hemodynamics facilitating uptitration of β-blocker therapy. It highlights the synergistic relationship of the two therapies and emphasizes the importance of optimizing medical therapy before and after CRT implantation.
Rachana Prasad; Peter J Pugh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of cardiovascular therapy     Volume:  10     ISSN:  1744-8344     ISO Abbreviation:  Expert Rev Cardiovasc Ther     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101182328     Medline TA:  Expert Rev Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  313-5     Citation Subset:  IM    
Department of Cardiology, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Box 263, Hills Road, Cambridge, CB2 0QQ, UK.
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