| Drug development for anxiety disorders: new roles for atypical antipsychotics. | |
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MedLine Citation:
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PMID: 17065969 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Anxiety disorders are prevalent and frequently comorbid with depression. Rates of response and remission for anxiety disorders are low despite marked improvements in treatment in the past several decades. Antidepressants and anxiolytics remain the most frequently prescribed agents for anxiety disorders, but the numbers of prescriptions for novel forms of therapy, such as anticonvulsants and atypical antipsychotics are increasing. For the atypical antipsychotics, agonist activity at the 5-HT(1A) receptor has been hypothesized to translate into anxiolytic effects. A small, but growing, literature suggests that atypical antipsychotics are useful as augmentation therapy for treatment of refractory anxiety disorders. The next generation antipsychotic, aripiprazole, has a unique mechanism of action (ie, combined D(2) and 5-HT(1A) partial agonist and 5-HT(2A) antagonist) and improves depressive and depressive/anxiety symptoms in patients with schizophrenia. Further studies examining the effect of aripiprazole and other atypical antipsychotic drugs on depressive and anxiety symptoms in patients with refractory anxiety disorders are warranted. |
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Authors:
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William H Carson; Hisashi Kitagawa; Charles B Nemeroff |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Psychopharmacology bulletin Volume: 38 Suppl 1 ISSN: 0048-5764 ISO Abbreviation: Psychopharmacol Bull Publication Date: 2004 |
Date Detail:
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Created Date: 2006-10-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0101123 Medline TA: Psychopharmacol Bull Country: United States |
Other Details:
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Languages: eng Pagination: 38-45 Citation Subset: IM |
Affiliation:
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Global Product Development/Aripiprazole, Princeton Aripiprazole Unit, Otsuka America Pharmaceutical, Inc., in Princeton, NJ. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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