Document Detail

Drug deposition of pressurized inhalation aerosols.
MedLine Citation:
PMID:  6954087     Owner:  NLM     Status:  MEDLINE    
When a pressurized inhalation aerosol is used, a high loss of drug substance occurs in the upper respiratory tract. This is explained by the rather slow propellant evaporation after the initial aerosol generation, and by the high initial aerosol velocity. Indirect measurements can be performed with a view to obtaining an indication of the deposition pattern in subjects; but a radioactive technique must be used in order to obtain the complete deposition pattern in the body. The drug loss occurring when a person exhales seems to be low compared to the dose entering a subject.
F Morén
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of respiratory diseases. Supplement     Volume:  119     ISSN:  0106-4347     ISO Abbreviation:  Eur J Respir Dis Suppl     Publication Date:  1982  
Date Detail:
Created Date:  1982-09-24     Completed Date:  1982-09-24     Revised Date:  2008-02-21    
Medline Journal Info:
Nlm Unique ID:  8010618     Medline TA:  Eur J Respir Dis Suppl     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  51-5     Citation Subset:  IM    
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MeSH Terms
Aerosol Propellants
Lung / drug effects*
Particle Size
Respiratory System / drug effects*
Respiratory Therapy*
Reg. No./Substance:
0/Aerosol Propellants; 0/Aerosols

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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