| Drug delivery by polymeric nanoparticles induces autophagy in macrophages. | |
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MedLine Citation:
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PMID: 22119964 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Drug delivery nanosystems are currently used in human therapy. In preliminary studies we have observed that Eudragit(®) RS nanoparticles, prepared by nanoprecipitation or double emulsion techniques, are cytotoxic for NR8383 rat macrophages. In this study, we expand our previous analysis and suggest that unloaded Eudragit(®) RS nanoparticles prepared by nanoprecipitation (NP/ERS) may induce important morphological and biochemical cellular modifications leading to cellular death. In NR8383 rat macrophages cell line exposed to doses varying from 15 to 100μg/mL, NP/ERS nanoparticles are internalized inside the cells reach the mitochondria and alter the structure of these organelles. In addition, the exposure to nanoparticles induces cellular autophagy as demonstrated by electron microscopy analysis, microchip array, qRT-PCR and Western blot assays. Although toxicity of nanoparticles has already been evidenced, it is the first time that results show clearly that the toxicity of nanovectors may be related to an activation of autophagy. |
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Authors:
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H Eidi; O Joubert; C Némos; S Grandemange; B Mograbi; B Foliguet; J Pego-Lima; P Maincent; A Lefaou; I Aboukhamis; B H Rihn |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-22 |
Journal Detail:
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Title: International journal of pharmaceutics Volume: - ISSN: 1873-3476 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Faculté de Pharmacie, EA 3452 CITHEFOR, Nancy-Université, 54001 Nancy Cedex, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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