| Drug delivery at the aortic valve tissues of healthy domestic pigs with a Paclitaxel-eluting valvuloplasty balloon. | |
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MedLine Citation:
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PMID: 19490359 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Restenosis occurs invariably within 1 year following balloon valvulopasty in aortic valve stenosis. The mechanism of restenosis seems to involve a dynamic cellular component that could be a target for drug inhibition. We investigated the feasibility of local drug delivery at the aortic valve tissues of healthy pigs with a paclitaxel-eluting balloon. METHODS: Aortic valvuloplasty was performed in eight anesthetized domestic pigs using paclitaxel-eluting balloons (3 micro2) balloon surface area). They were assigned to two or four times 15-second balloon inflations and were sacrificed 30 minutes after final balloon inflation. RESULTS: The aortic annulus to balloon diameter ratio was 1.15 +/- 0.07. The mean paclitaxel concentration in the aortic valve leaflets was 0.91 +/- 1.36 micro (0.34 +/- 0.05 micro in the two-inflation group, 1.48 +/- 1.86 micro in the four-inflation group, P = 0.23). The percentage of the total paclitaxel dose recovered in the aortic valve leaflets was 18 +/- 11(-6)% (13 +/- 6(-6)% and 25 +/- 14(-6)% in the two- and four-inflation group, P = 0.16). CONCLUSION: Local drug delivery at the aortic valve leaflets of healthy pigs with a paclitaxel-eluting balloon is feasible and concentrations within the therapeutic window are detected 30 minutes after the procedure. The antirestenotic potential of this treatment should be studied. |
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Authors:
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Konstantinos Spargias; Krzystof Milewski; Marcin Debinski; Piotr P Buszman; Dennis V Cokkinos; Rembert Pogge; Pawel Buszman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-13 |
Journal Detail:
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Title: Journal of interventional cardiology Volume: 22 ISSN: 1540-8183 ISO Abbreviation: J Interv Cardiol Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-07-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8907826 Medline TA: J Interv Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 291-8 Citation Subset: IM |
Affiliation:
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Onassis Cardiac Surgery Centre, Athens, Greece. spargias@ocsc.gr |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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