Document Detail

Drug contamination of the equine racetrack environment: a preliminary examination.
MedLine Citation:
PMID:  19000266     Owner:  NLM     Status:  MEDLINE    
Advances in analytical technology now make it feasible to detect and confirm exceptionally low concentrations (pg to fg/mL) of drugs and their metabolites in equine biological fluids. These new capabilities complicate the regulatory interpretation of drug positives and bring into question the fair application of medication rules. Such approaches and policies are further complicated by the possibility that drug positives may arise from contamination of the equine environment on the backstretch of the race track. This manuscript provides data demonstrating that the general environment of the backstretch in which horses live is contaminated with therapeutic drugs and drugs of human origin. The major contaminants are nonsteroidal anti-inflammatory drugs, such as flunixin, phenylbutazone and naproxen, present in the soil in stalls, on stall surfaces, in the dust that circulates and in the lagoon waters that accumulate on the backstretch. The presence of caffeine and cotinine suggest other possible vectors for contamination by humans. Concentrations of these compounds as well as their frequency of occurrence are provided.
S A Barker
Related Documents :
10756536 - Loteprednol etabonate: a review of ophthalmic clinical studies.
21392426 - Mycobacterium tuberculosis cluster with developing drug resistance, new york, new york,...
1382876 - Inhibitory effects of some natural products on the activation of hyaluronidase and thei...
2281576 - Retroperitoneal fibrosis.
22877926 - What do we know about the reduction of pt(iv) pro-drugs?
3960966 - Pulmonary absorption of drugs in the dog: comparison with other species.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of veterinary pharmacology and therapeutics     Volume:  31     ISSN:  1365-2885     ISO Abbreviation:  J. Vet. Pharmacol. Ther.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-11-12     Completed Date:  2009-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910920     Medline TA:  J Vet Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  466-71     Citation Subset:  IM    
Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / analysis*
Caffeine / analysis
Clonixin / analogs & derivatives,  analysis
Dust / analysis*
Environmental Pollutants / analysis*
Fresh Water / analysis*
Gas Chromatography-Mass Spectrometry
Housing, Animal*
Naproxen / analysis
Pharmaceutical Preparations / analysis*
Phenylbutazone / analysis
Soil / analysis*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Dust; 0/Environmental Pollutants; 0/Pharmaceutical Preparations; 0/Soil; 17737-65-4/Clonixin; 22204-53-1/Naproxen; 38677-85-9/flunixin; 50-33-9/Phenylbutazone; 58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A pilot study: sodium urate synovitis as an acute model of inflammatory response using objective and...
Next Document:  The effect of sesame and sunflower oils on the plasma disposition of ivermectin in goats.