| Drug- and chemical-induced aseptic meningitis: a review of the literature. | |
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MedLine Citation:
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PMID: 1611165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The primary objective of this article is to provide readers with case reports of drug- or chemical-induced aseptic meningitis (DCAM) described in the medical literature. Background information regarding the classification of DCAM, incidence, proposed mechanisms, associated risk factors, clinical management, and sequelae is presented. DATA SOURCES: A MEDLINE search was used to identify pertinent background literature and case reports of DCAM. DATA EXTRACTION: All case reports of DCAM involve anecdotal information. A critical analysis of a causal relationship to the implicated drug or chemical and the appearance of meningeal involvement is presented. Animal data are included when pertinent. DATA SYNTHESIS: DCAM is a rare adverse event associated with numerous agents. Patients present with a variety of clinical signs and symptoms and laboratory findings of cerebral spinal fluid, when obtained, vary greatly. Most patients fully recover without sequelae. CONCLUSIONS: Numerous drugs and chemicals have been implicated in the medical literature as producing DCAM. Two proposed mechanisms of DCAM have been theorized: a delayed hypersensitivity-type reaction and direct meningeal irritation. The nonsteroidal antiinflammatory drugs, certain antibiotics, radiographic agents, and muromonab-CD3 have been most frequently implicated. There appears to be an association between the occurrence of the hypersensitivity-type reactions and underlying collagen vascular or rheumatologic disease. |
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Authors:
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J S Marinac |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Annals of pharmacotherapy Volume: 26 ISSN: 1060-0280 ISO Abbreviation: Ann Pharmacother Publication Date: 1992 Jun |
Date Detail:
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Created Date: 1992-07-29 Completed Date: 1992-07-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 813-22 Citation Subset: IM |
Affiliation:
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Department of Medicine, School of Medicine, University of Missouri-Kansas City. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Infective Agents
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adverse effects Anti-Inflammatory Agents, Non-Steroidal / adverse effects Drug Hypersensitivity / complications Humans Hypersensitivity, Delayed / complications Lupus Erythematosus, Systemic / complications Meningitis, Aseptic / cerebrospinal fluid, chemically induced*, diagnosis Recurrence Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Anti-Inflammatory Agents, Non-Steroidal |
| Comments/Corrections | |
Comment In:
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Ann Pharmacother. 2004 Jan;38(1):172
[PMID:
14742817
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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