| Drug-associated reversible granulomatous T cell dyscrasia: a distinct subset of the interstitial granulomatous drug reaction. | |
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MedLine Citation:
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PMID: 20482682 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A cutaneous T-cell infiltrate exhibiting cytologic and architectural atypia, an aberrant phenotypic profile and clonal restriction would fall under the rubric of a T-cell dyscrasia. Although such an infiltrate could represent a lymphoma, this constellation of findings can also be seen in drug-associated pseudolymphoma. METHODS: In 2001, two of the authors (CMM and AEC) proposed the term reversible T-cell dyscrasia to describe atypical T-lymphocytic infiltrates that manifest a light microscopic, phenotypic and molecular profile that closely parallels cutaneous T-cell lymphoma but regress when the causal drug is withdrawn. RESULTS: Herein we report our 10 cases of drug-associated pseudolymphoma resembling granulomatous mycosis fungoides. CONCLUSIONS: We term this reaction pattern drug-associated reversible granulomatous T-cell dyscrasia and consider it a distinct subset of the interstitial granulomatous drug reaction. |
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Authors:
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Cynthia M Magro; Andres E Cruz-Inigo; Henry Votava; Michael Jacobs; David Wolfe; A Neil Crowson |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of cutaneous pathology Volume: 37 Suppl 1 ISSN: 1600-0560 ISO Abbreviation: J. Cutan. Pathol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-20 Completed Date: 2010-08-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0425124 Medline TA: J Cutan Pathol Country: Denmark |
Other Details:
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Languages: eng Pagination: 96-111 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA. cym2003@med.cornell.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Angiotensin-Converting Enzyme Inhibitors / adverse effects Anticonvulsants / adverse effects Antidepressive Agents / adverse effects Biopsy Drug Eruptions / immunology*, pathology* Female Granuloma / immunology*, pathology* Humans Lymphoma, T-Cell, Cutaneous / immunology, pathology Male Middle Aged Precancerous Conditions / immunology, pathology Skin Neoplasms / immunology, pathology T-Lymphocytes / pathology* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Anticonvulsants; 0/Antidepressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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