| Drug screening for Huntington's disease and other neurodegenerative disorders. | |
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MedLine Citation:
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PMID: 20858196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Devising therapies for neurodegenerative diseases remains a major challenge due to the complex etiology, prolonged disease course and the paucity of validated targets. These factors make it difficult to model neurodegenerative diseases in a manner amenable to large-scale screening. However recent developments in automation, combinatorial chemistry and high-throughput phenotypic assays have presented new opportunities for discovering small molecule therapeutics for neurodegenerative diseases. This review focuses on novel in vitro and phenotypic screens for Huntington's disease and a few other neurodegenerative diseases. The lessons learned from these screens and the potential of the small molecules identified as therapeutic leads are discussed. |
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Authors:
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Hemant Varma |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current molecular pharmacology Volume: 3 ISSN: 1874-4702 ISO Abbreviation: Curr Mol Pharmacol Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-15 Completed Date: 2011-03-01 Revised Date: 2012-04-18 |
Medline Journal Info:
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Nlm Unique ID: 101467997 Medline TA: Curr Mol Pharmacol Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 164-73 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Columbia University, 614 Fairchild Building, New York, NY 10027, USA. hv2108@columbia.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Disease Models, Animal Drug Evaluation, Preclinical High-Throughput Screening Assays Huntington Disease / drug therapy* Neurodegenerative Diseases / drug therapy* Protein Processing, Post-Translational Proteins / chemistry, metabolism, toxicity Reactive Oxygen Species / metabolism Small Molecule Libraries / chemistry*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Proteins; 0/Reactive Oxygen Species; 0/Small Molecule Libraries |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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