Document Detail


Drug screening for Huntington's disease and other neurodegenerative disorders.
MedLine Citation:
PMID:  20858196     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Devising therapies for neurodegenerative diseases remains a major challenge due to the complex etiology, prolonged disease course and the paucity of validated targets. These factors make it difficult to model neurodegenerative diseases in a manner amenable to large-scale screening. However recent developments in automation, combinatorial chemistry and high-throughput phenotypic assays have presented new opportunities for discovering small molecule therapeutics for neurodegenerative diseases. This review focuses on novel in vitro and phenotypic screens for Huntington's disease and a few other neurodegenerative diseases. The lessons learned from these screens and the potential of the small molecules identified as therapeutic leads are discussed.
Authors:
Hemant Varma
Related Documents :
16806186 - Oxidative stress in the brain at early preclinical stages of mouse scrapie.
9747926 - Amyotrophic lateral sclerosis: an introduction.
19783656 - Differential involvement of atg16l1 in crohn disease and canonical autophagy: analysis ...
11081516 - Identification of genes that modify ataxin-1-induced neurodegeneration.
16932506 - Drug insight: using statins to treat neuroinflammatory disease.
24291866 - Als disease modeling and drug screening using patient-specific ips cells.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current molecular pharmacology     Volume:  3     ISSN:  1874-4702     ISO Abbreviation:  Curr Mol Pharmacol     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-15     Completed Date:  2011-03-01     Revised Date:  2012-04-18    
Medline Journal Info:
Nlm Unique ID:  101467997     Medline TA:  Curr Mol Pharmacol     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  164-73     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, Columbia University, 614 Fairchild Building, New York, NY 10027, USA. hv2108@columbia.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Disease Models, Animal
Drug Evaluation, Preclinical
High-Throughput Screening Assays
Huntington Disease / drug therapy*
Neurodegenerative Diseases / drug therapy*
Protein Processing, Post-Translational
Proteins / chemistry,  metabolism,  toxicity
Reactive Oxygen Species / metabolism
Small Molecule Libraries / chemistry*,  therapeutic use
Chemical
Reg. No./Substance:
0/Proteins; 0/Reactive Oxygen Species; 0/Small Molecule Libraries

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Edible plants, their secondary metabolites and antiobesogenic potential.
Next Document:  Biological activities of natural and engineered cyclotides, a novel molecular scaffold for peptide-b...