Document Detail

Drug-Induced Lupus Associated with Rifabutin and Literature Review.
MedLine Citation:
PMID:  23442494     Owner:  NLM     Status:  Publisher    
Drug-induced lupus (DIL) is a rare adverse reaction to medications with features resembling idiopathic systemic lupus erythromatosis. Rifabutin/rifamycins have only rarely been reported as a cause of DIL, and no cases have been reported in blacks. A 55-year-old African American woman with HIV presented with severe generalized arthralgias and recurrent oral ulcers while receiving treatment for tuberculous meningitis. Arthralgias, which began in her knees after 5 weeks of antituberculous therapy, progressed to involve the joints in the ankles, wrists, and hands. She had no associated fever or rash. When she had these symptoms her antinuclear antibody (ANA) was 1:1280 homogenous pattern, antidouble stranded DNA was negative, antihistone antibody was strongly positive, anti-smith and antiribonucleoprotein (anti-RNP) were negative. Her symptoms resolved within 2 months of stopping rifabutin while continuing other antituberculous medications and her ANA titer started to decrease. We review the existing literature on this subject.
Henry Anyimadu; Naseem Saadia; Sharon Mannheimer
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-26
Journal Detail:
Title:  Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)     Volume:  -     ISSN:  1545-1097     ISO Abbreviation:  J Int Assoc Physicians AIDS Care (Chic)     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101185740     Medline TA:  J Int Assoc Physicians AIDS Care (Chic)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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