Document Detail

Drug-induced graves disease from CTLA-4 receptor suppression.
MedLine Citation:
PMID:  21242854     Owner:  NLM     Status:  MEDLINE    
Monoclonal antibody, ipilimumab, useful for treatment of metastatic melanoma, blocks CTLA-4 mediated T-cell suppression and can also cause a Graves ophthalmopathy like syndrome. Epidemiologic study has linked variant polymorphisms of CTLA-4 receptor gene to the presence of thyroid eye disease. The combination of these observations suggests CTLA-4 mediated T-cell functions are important to the pathogenesis of thyroid-associated eye disease.
Gary Borodic; David M Hinkle; Yihong Cia
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Ophthalmic plastic and reconstructive surgery     Volume:  27     ISSN:  1537-2677     ISO Abbreviation:  Ophthal Plast Reconstr Surg     Publication Date:    2011 Jul-Aug
Date Detail:
Created Date:  2011-07-12     Completed Date:  2011-09-21     Revised Date:  2013-06-21    
Medline Journal Info:
Nlm Unique ID:  8508431     Medline TA:  Ophthal Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e87-8     Citation Subset:  IM    
Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02142, USA.
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MeSH Terms
Antibodies, Monoclonal / adverse effects*
Antigens, CD / drug effects*
Antineoplastic Agents / adverse effects*
CTLA-4 Antigen
Diplopia / chemically induced
Exophthalmos / chemically induced
Graves Ophthalmopathy / chemically induced*
Lung Neoplasms / drug therapy,  secondary
Magnetic Resonance Imaging
Melanoma / drug therapy,  secondary
Middle Aged
Neoplasms, Unknown Primary / drug therapy,  pathology
Oculomotor Muscles / drug effects
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, CD; 0/Antineoplastic Agents; 0/CTLA-4 Antigen; 0/CTLA4 protein, human; 0/ipilimumab
Comment In:
Ophthal Plast Reconstr Surg. 2013 May-Jun;29(3):239-40   [PMID:  23652294 ]
Ophthal Plast Reconstr Surg. 2013 May-Jun;29(3):241   [PMID:  23652295 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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