| Drug-Induced Graves Disease From CTLA-4 Receptor Suppression. | |
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MedLine Citation:
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PMID: 21242854 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Monoclonal antibody, ipilimumab, useful for treatment of metastatic melanoma, blocks CTLA-4 mediated T-cell suppression and can also cause a Graves ophthalmopathy like syndrome. Epidemiologic study has linked variant polymorphisms of CTLA-4 receptor gene to the presence of thyroid eye disease. The combination of these observations suggests CTLA-4 mediated T-cell functions are important to the pathogenesis of thyroid-associated eye disease. |
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Authors:
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Gary Borodic; David M Hinkle; Yihong Cia |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-14 |
Journal Detail:
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Title: Ophthalmic plastic and reconstructive surgery Volume: - ISSN: 1537-2677 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508431 Medline TA: Ophthal Plast Reconstr Surg Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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*Massachusetts Eye and Ear Infirmary, Boston; †Ocular Immunology and Uveitis Foundation, Cambridge; and ‡Harvard Medical School, Boston, Massachusetts, U.S.A. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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