Document Detail

Drug-eluting stents versus bare-metal stents in acute ST-segment elevation myocardial infarction. a single-center experience with long-term follow up.
MedLine Citation:
PMID:  20351384     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To compare the efficacy and safety of drugeluting stents (DES) vs. bare-metal stents (BMS) in patients with acute ST-segment-elevation myocardial infarction (STEMI). BACKGROUND: DES effectively reduce restenosis in elective percutaneous coronary intervention. Limited data are available about the use of DES in patients with STEMI. METHODS: 453 consecutive patients who presented with STEMI between July 2003 and May 2006 were studied. The procedural characteristics, 30-day, 12-, 18- and 26-month outcomes of 277 patients treated with DES were compared with 176 patients treated with BMS. RESULTS: At 26-month follow up, DES therapy was associated with a significant decrease in major adverse cardiac events (MACE) (relative risk [RR] -35%; p = 0.01) and target lesion revascularization [TLR], RR -64%; p = 0.009). The DES group included more diabetic patients (20% vs. 9%; p < 0.001), and the stents were longer (22 +/- 0.28 mm vs. 19.4 +/- 0.36 mm; p < 0.001) and smaller (diameter: 2.9 +/- 0.02 mm vs. 3.1 +/- 0.02 mm; p < 0.001). The rate of stent thrombosis was similar and the prolonged combined antiplatelet therapy was an independent factor predicting a protective effect on MACE. CONCLUSIONS: DES reduce the incidence of TLR and MACE in patients with STEMI without evidence of additional risks at 2-year follow up. DES therapy was associated with more complex interventional techniques, which yielded similar procedural results and clinical outcomes that may be influenced by prolonged combined antiplatelet therapy.
Cataldo Palmieri; Marcello Ravani; Giuseppe Trianni; Jacopo Gianetti; Marco Vaghetti; Antonio Rizza; Umberto Paradossi; Arton Beqiri; Sergio Berti
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of invasive cardiology     Volume:  22     ISSN:  1557-2501     ISO Abbreviation:  J Invasive Cardiol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-30     Completed Date:  2010-08-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8917477     Medline TA:  J Invasive Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  151-8     Citation Subset:  IM    
Gabriele Monasterio Foundation, and Institute of Clinical Physiology CNR, National Research Council G Pasquinucci Hospital, Massa, Italy.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary / instrumentation*
Antibiotics, Antineoplastic / administration & dosage*
Antineoplastic Agents, Phytogenic / administration & dosage*
Cohort Studies
Coronary Angiography
Drug-Eluting Stents*
Follow-Up Studies
Middle Aged
Myocardial Infarction / therapy*
Paclitaxel / administration & dosage*
Prosthesis Design
Retrospective Studies
Sirolimus / administration & dosage*
Treatment Outcome
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Antineoplastic Agents, Phytogenic; 0/Metals; 33069-62-4/Paclitaxel; 53123-88-9/Sirolimus
Comment In:
J Invasive Cardiol. 2010 Apr;22(4):159-60   [PMID:  20351385 ]

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