Document Detail


Drug discovery from marine microbes.
MedLine Citation:
PMID:  23274881     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The marine environment has been a source of more than 20,000 inspirational natural products discovered over the past 50 years. From these efforts, 9 approved drugs and 12 current clinical trial agents have been discovered, either as natural products or as molecules inspired from the natural product structure. To a significant degree, these have come from collections of marine invertebrates largely obtained from shallow-water tropical ecosystems. However, there is a growing recognition that marine invertebrates are oftentimes populated with enormous quantities of "associated" or symbiotic microorganisms and that microorganisms are the true metabolic sources of these most valuable of marine natural products. Also, because of the inherently multidisciplinary nature of this field, a high degree of innovation is characteristic of marine natural product drug discovery efforts.
Authors:
William H Gerwick; Amanda M Fenner
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-12-30
Journal Detail:
Title:  Microbial ecology     Volume:  65     ISSN:  1432-184X     ISO Abbreviation:  Microb. Ecol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-29     Completed Date:  2013-11-04     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  7500663     Medline TA:  Microb Ecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  800-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Aquatic Organisms / chemistry*,  microbiology,  physiology
Bacteria / metabolism*
Biological Products / chemistry*,  metabolism
Drug Discovery*
Invertebrates / chemistry*,  microbiology,  physiology
Seawater / microbiology
Symbiosis
Grant Support
ID/Acronym/Agency:
CA100851/CA/NCI NIH HHS; CA108874/CA/NCI NIH HHS; NS053398/NS/NINDS NIH HHS; R01 CA100851/CA/NCI NIH HHS; R01 CA108874/CA/NCI NIH HHS; R01 NS053398/NS/NINDS NIH HHS; TW006634/TW/FIC NIH HHS; U01 TW006634/TW/FIC NIH HHS
Chemical
Reg. No./Substance:
0/Biological Products
Comments/Corrections

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