| Drospirenone and cardiovascular risk in lean and obese polycystic ovary syndrome patients: a pilot study. | |
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MedLine Citation:
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PMID: 19913778 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We sought to verify if an oral contraceptive (OC) containing drospirenone affects the cardiovascular risk of patients with polycystic ovary syndrome (PCOS). STUDY DESIGN: A total of 28 women with PCOS (16 lean [group A] and 12 overweight [group B]) were assessed at baseline and after 6 months therapy with an OC. Leptin, homocysteine, endothelin-1, and flow-mediated dilatation of brachial artery were measured. RESULTS: The brachial artery diameter and the pulsatility index, after the reactive hyperemia, did not change in group A; it improved significantly in group B after 6 months of treatment. At baseline and after therapy the plasma levels of homocysteine and endothelin-1 did not differ among the groups. Leptin was significantly lower at baseline in group A compared to group B. CONCLUSION: The OC containing drospirenone does not seem to affect the surrogate markers of cardiovascular risk in lean patients with PCOS. |
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Authors:
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Fulvia Mancini; Arianna Cianciosi; Nicola Persico; Fabio Facchinetti; Paolo Busacchi; Cesare Battaglia |
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Publication Detail:
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Type: Journal Article Date: 2009-11-14 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 202 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 169.e1-8 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, University of Bologna, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aldosterone Antagonists / pharmacology* Androstenes / pharmacology* Brachial Artery / physiopathology Cardiovascular Diseases / etiology* Contraceptives, Oral / pharmacology Endothelin-1 / blood Female Homocysteine / blood Humans Insulin / blood Insulin Resistance Leptin / blood Obesity / complications* Pilot Projects Polycystic Ovary Syndrome / complications* |
| Chemical | |
Reg. No./Substance:
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0/Aldosterone Antagonists; 0/Androstenes; 0/Contraceptives, Oral; 0/Endothelin-1; 0/Leptin; 11061-68-0/Insulin; 454-28-4/Homocysteine; 67392-87-4/drospirenone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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