Document Detail


The Drosophila roughened mutation: activation of a rap homolog disrupts eye development and interferes with cell determination.
MedLine Citation:
PMID:  1934069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Roughened is a dominant mutation of D. melanogaster that disrupts eye development. The majority of the ommatidia in the adult eye lack a single photoreceptor cell, which is most commonly the R7 cell. The Roughened mutation disrupts the early stages of photoreceptor cell determination. Roughened is a dominant gain-of-function mutation that results from a single amino acid change (Phe157 to Leu) in the Drosophila Rap1 protein. Loss of function Rap1 mutations are lethal. Drosophila Rap1 protein is 88% identical to human rap1A/K-rev1 protein, a putative antagonist of ras action.
Authors:
I K Hariharan; R W Carthew; G M Rubin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell     Volume:  67     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1991-12-26     Completed Date:  1991-12-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  717-22     Citation Subset:  IM    
Affiliation:
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/M80535;  M80539;  S60911;  S60914;  S60917;  S60919;  S60920;  S60969;  S61522;  S61524
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Drosophila melanogaster / embryology*,  genetics
Eye / embryology*
GTP-Binding Proteins / physiology*
Genes, Dominant
Molecular Sequence Data
Mutation
Sequence Alignment
rap GTP-Binding Proteins
Chemical
Reg. No./Substance:
EC 3.6.1.-/GTP-Binding Proteins; EC 3.6.5.2/rap GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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