Document Detail

Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation.
MedLine Citation:
PMID:  12403718     Owner:  NLM     Status:  MEDLINE    
Ciliated neurons play an important role in sensory perception in many animals. Modified cilia at dendrite endings serve as sites of sensory signal capture and transduction. We describe Drosophila mutations that affect the transcription factor RFX and genetic rescue experiments that demonstrate its central role in sensory cilium differentiation. Rfx mutant flies show defects in chemosensory and mechanosensory behaviors but have normal phototaxis, consistent with Rfx expression in ciliated sensory neurons and neuronal precursors but not in photoreceptors. The mutant behavioral phenotypes are correlated with abnormal function and structure of neuronal cilia, as shown by the loss of sensory transduction and by defects in ciliary morphology and ultrastructure. These results identify Rfx as an essential regulator of ciliated sensory neuron differentiation in Drosophila.
Raphaelle Dubruille; Anne Laurençon; Camille Vandaele; Emiko Shishido; Madeleine Coulon-Bublex; Peter Swoboda; Pierre Couble; Maurice Kernan; Bénédicte Durand
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  129     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-10-29     Completed Date:  2003-01-21     Revised Date:  2012-10-26    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  5487-98     Citation Subset:  IM    
Centre de Génétique Moléculaire et Cellulaire, CNRS UMR-5534, Université Claude Bernard Lyon-1, 69622 Villeurbanne, France.
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MeSH Terms
Amino Acid Sequence
Cell Differentiation / physiology*
Cilia / physiology*
DNA-Binding Proteins / genetics,  metabolism*
Drosophila Proteins / genetics,  metabolism
Drosophila melanogaster / genetics,  physiology*
Genes, Insect
Molecular Sequence Data
Neurons, Afferent / physiology*,  ultrastructure
Recombinant Fusion Proteins / genetics,  metabolism
Sequence Alignment
Transcription Factors / genetics,  metabolism*
Grant Support
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Recombinant Fusion Proteins; 0/Transcription Factors; 0/regulatory factor X transcription factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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