Document Detail


Drosophila neuroblasts: a model for stem cell biology.
MedLine Citation:
PMID:  23132240     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Drosophila neuroblasts, the stem cells of the developing fly brain, have emerged as a key model system for neural stem cell biology and have provided key insights into the mechanisms underlying asymmetric cell division and tumor formation. More recently, they have also been used to understand how neural progenitors can generate different neuronal subtypes over time, how their cell cycle entry and exit are coordinated with development, and how proliferation in the brain is spared from the growth restrictions that occur in other organs upon starvation. In this Primer, we describe the biology of Drosophila neuroblasts and highlight the most recent advances made using neuroblasts as a model system.
Authors:
Catarina C F Homem; Juergen A Knoblich
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  139     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-07     Completed Date:  2013-01-16     Revised Date:  2013-03-14    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  4297-310     Citation Subset:  IM    
Affiliation:
Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Dr Bohr Gasse 3-5, 1030 Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Animals
Asymmetric Cell Division*
Brain / embryology
Cell Cycle
Cell Differentiation*
Cell Division
Cell Transformation, Neoplastic
Drosophila / cytology,  embryology*
Gene Expression Regulation, Developmental
Neural Stem Cells / cytology*,  metabolism*
Neurogenesis
Neuroglia
Transcription Factors / metabolism
Grant Support
ID/Acronym/Agency:
250342//European Research Council
Chemical
Reg. No./Substance:
0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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