| Drosophila neuroblast asymmetric cell division: recent advances and implications for stem cell biology. | |
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MedLine Citation:
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PMID: 16815328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Asymmetric cell division is an evolutionarily conserved mechanism widely used to generate cellular diversity during development. Drosophila neuroblasts have been a useful model system for studying the molecular mechanisms of asymmetric cell division. In this minireview, we focus on recent progress in understanding the role of heterotrimeric G proteins and their regulators in asymmetric spindle geometry, as well as the role of an Inscuteable-independent microtubule pathway in asymmetric localization of proteins in neuroblasts. We also discuss issues of progenitor proliferation and differentiation associated with asymmetric cell division and their broader implications for stem cell biology. |
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Authors:
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Fengwei Yu; Chay T Kuo; Yuh Nung Jan |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Neuron Volume: 51 ISSN: 0896-6273 ISO Abbreviation: Neuron Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-03 Completed Date: 2006-08-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8809320 Medline TA: Neuron Country: United States |
Other Details:
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Languages: eng Pagination: 13-20 Citation Subset: IM |
Affiliation:
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Howard Hughes Medical Institute and Departments of Physiology, Biochemistry, and Biophysics, University of California, Rock Hall, 1550 Fourth Street, San Francisco, California 94143, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / physiology Cell Division / physiology* Cell Proliferation Drosophila Proteins / genetics, metabolism Drosophila melanogaster / cytology, embryology*, physiology Embryo, Nonmammalian / cytology, embryology*, physiology GTP-Binding Proteins / metabolism* Microtubules / metabolism, ultrastructure Mitotic Spindle Apparatus / metabolism*, ultrastructure Stem Cells / cytology, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins; EC 3.6.1.-/GTP-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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