| Drosophila midgut homeostasis involves neutral competition between symmetrically dividing intestinal stem cells. | |
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MedLine Citation:
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PMID: 22522699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Drosophila adult posterior midgut has been identified as a powerful system in which to study mechanisms that control intestinal maintenance, in normal conditions as well as during injury or infection. Early work on this system has established a model of tissue turnover based on the asymmetric division of intestinal stem cells. From the quantitative analysis of clonal fate data, we show that tissue turnover involves the neutral competition of symmetrically dividing stem cells. This competition leads to stem-cell loss and replacement, resulting in neutral drift dynamics of the clonal population. As well as providing new insight into the mechanisms regulating tissue self-renewal, these findings establish intriguing parallels with the mammalian system, and confirm Drosophila as a useful model for studying adult intestinal maintenance. |
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Authors:
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Joaquín de Navascués; Carolina N Perdigoto; Yu Bian; Markus H Schneider; Allison J Bardin; Alfonso Martínez-Arias; Benjamin D Simons |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-04-20 |
Journal Detail:
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Title: The EMBO journal Volume: 31 ISSN: 1460-2075 ISO Abbreviation: EMBO J. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-31 Completed Date: 2012-08-13 Revised Date: 2013-05-01 |
Medline Journal Info:
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Nlm Unique ID: 8208664 Medline TA: EMBO J Country: England |
Other Details:
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Languages: eng Pagination: 2473-85 Citation Subset: IM |
Affiliation:
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Department of Genetics, University of Cambridge, Cambridge, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / physiology Cell Division* Cell Lineage / physiology Cell Proliferation Drosophila melanogaster / cytology, physiology* Female Homeostasis / physiology* Intestines / cytology, physiology* Stem Cells / cytology, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Comments/Corrections | |
Comment In:
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EMBO J. 2012 May 30;31(11):2441-3
[PMID:
22580826
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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