| Drosophila metabolize 1,4-butanediol into gamma-hydroxybutyric acid in vivo. | |
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MedLine Citation:
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PMID: 12892832 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A solvent, 1,4-butanediol, is also abused as a recreational drug. In mammals, 1,4-butanediol is metabolized into gamma-hydroxybutyric acid (GHB), which stimulates metabotropic gamma-aminobutyric acid (GABA) GABAB and putative GHB receptors. Here we show that in vivo injection of 1,4-butanediol into adult Drosophila leads to GHB synthesis (GHB was detectable 5 min after 1,4-butanediol injection and increased dramatically 1-2 h later). This synthesis of GHB was accompanied by an impairment of locomotor activity that was mimicked by a direct injection of GHB into flies. We propose Drosophila as a model to study the molecular actions of 1,4-butanediol and GHB. |
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Authors:
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Rosalba Satta; Nikola Dimitrijevic; Hari Manev |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: European journal of pharmacology Volume: 473 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-08-01 Completed Date: 2004-07-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 149-52 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Butylene Glycols / metabolism* Drosophila melanogaster / metabolism* Gas Chromatography-Mass Spectrometry Male Sodium Oxybate / metabolism* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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R03DA14811/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Butylene Glycols; 110-63-4/1,4-butanediol; 502-85-2/Sodium Oxybate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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