Document Detail


Drosophila lacks C20 and C22 PUFAs.
MedLine Citation:
PMID:  20656917     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Drosophila melanogaster has been considered a model organism for investigating human diseases and genetic pathways. Whether Drosophila is an ideal model for nutrigenomics, especially for FA metabolism, however, remains to be illustrated. The aim of this study was to examine the metabolism of C20 and C22 PUFAs in Drosophila. Analysis of FA composition revealed a complete lack of C20 and C22 PUFAs in the body tissue of larvae, pupae, and adult flies fed either a base or supplemented diet abundant in the PUFA precursors linoleic acid and α-linolenic acid. PUFA with >C20 could only be found in flies supplemented with specific FAs. Interestingly, the supplemented C22 PUFAs docosahexaenoic acid (22:6n-3) and docosatetraenoic acid (22:4n-6) were largely converted to the shorter chain C20 PUFAs eicosapentaenoic acid (20:5n-3) and arachidonic acid (20:4n-6), respectively. Furthermore, a genome sequence scan indicated that no gene encoding Δ-6/ Δ-5 desaturases, the key enzymes for the synthesis of C20/C22 PUFA, was present in Drosophila. These findings demonstrate that Drosophila lacks the capability to synthesize the biologically important C20 and C22 PUFAs, and thereby argue that Drosophila is not a valid model for the study of lipid metabolism and related diseases.
Authors:
Li Rong Shen; Chao Qiang Lai; Xiang Feng; Laurence D Parnell; Jian Bo Wan; Jing D Wang; Duo Li; Jose M Ordovas; Jing X Kang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-07-23
Journal Detail:
Title:  Journal of lipid research     Volume:  51     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-10     Completed Date:  2011-01-24     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2985-92     Citation Subset:  IM    
Affiliation:
Department of Food Science & Nutrition, Zhejiang University, Hangzhou, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Drosophila / metabolism*
Fatty Acid Desaturases / metabolism
Fatty Acids, Unsaturated / metabolism*
Grant Support
ID/Acronym/Agency:
CA-113605/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Unsaturated; EC 1.14.19.-/Fatty Acid Desaturases
Comments/Corrections

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