| The Drosophila insulin receptor contains a novel carboxyl-terminal extension likely to play an important role in signal transduction. | |
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MedLine Citation:
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PMID: 7876183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The nucleic acid and deduced amino acid sequence of the Drosophila insulin receptor homologue (dir) has been determined. The coding sequence of dir is contained within 10 exons spanning less than 8 kilobase pairs of genomic DNA. The deduced amino acid sequence of the dir encodes a protein of 2148 amino acids, larger than the human insulin receptor due to amino- and carboxyl-terminal extensions. The overall level of amino acid identity between the DIR and human insulin and insulin-like growth factor-I receptors is 32.5 and 33.3%, respectively. Higher levels of identity are found in exon 2 (45 and 43%, respectively) and in the beta subunit (50 and 48%, respectively), and the positions of most cysteine residues in the alpha subunit cysteine-rich domain are conserved. A novel, 400-amino acid, carboxyl-terminal extension contains 9 tyrosine residues, four of which are present in YXXM or YXXL motifs, suggesting that they function as binding sites for SH2 domain-containing signaling proteins. The presence of multiple putative SH2 domain binding sites in the DIR represents a significant difference from its mammalian homologues and suggests that, unlike the human insulin and insulin-like growth factor-I receptors, the DIR forms stable complexes with signaling molecules as part of its signal transduction mechanism. |
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Authors:
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Y Ruan; C Chen; Y Cao; R S Garofalo |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The Journal of biological chemistry Volume: 270 ISSN: 0021-9258 ISO Abbreviation: J. Biol. Chem. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-04-05 Completed Date: 1995-04-05 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 4236-43 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Cell Biology, State University of New York, Health Science Center at Brooklyn 11203. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/U18351 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Base Sequence DNA Primers DNA, Complementary Drosophila / metabolism* Humans Molecular Sequence Data Receptor, Insulin / chemistry, metabolism* Sequence Homology, Amino Acid Signal Transduction* |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/DNA, Complementary; EC 2.7.10.1/Receptor, Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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