| Drosophila filamin is required for follicle cell motility during oogenesis. | |
| | |
MedLine Citation:
|
PMID: 12885568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The Filamin family of actin binding proteins is required to maintain cell shape and promote cell locomotion. Using the Drosophila ovary, we provide a detailed description of Filamin-deficient cells during morphogenesis. Reduced expression of Filamin in follicle cells causes defects in the initial encapsulation of germline cysts and in the migration of border cells through the germline cyst. However, follicle cell morphogenesis is unaffected by point mutations that produce truncated Filamin proteins. In addition, mutant follicle cell movements can be partially rescued by a transgene encoding only the actin-binding domain and the first six filamin repeats. These data show that Filamin function in cell motility can be provided by a truncated Filamin protein that resembles Dictyostelium Actin Binding Protein-120. |
| | |
Authors:
|
Nicholas S Sokol; Lynn Cooley |
Related Documents
:
|
9571568 - Interleukin-1 beta fragment (163-171) modulates bovine granulosa cell proliferation in ... 2040858 - Conversion of 5(10)-oestrene-3 beta,17 beta-diol to 19-nor-4-ene-3-ketosteroids by lute... 1581068 - Microvillus growth and m-cell formation in mouse peyer's patch follicle-associated epit... 20444928 - Granulosa cell subtypes vary in response to oxidized low-density lipoprotein as regards... 2690328 - Structure and function of endocrine cells in the oxyntic (acid-secreting) mucosa of hum... 6420188 - Guanosine triphosphate catabolism in purine nucleoside phosphorylase deficient human b ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Developmental biology Volume: 260 ISSN: 0012-1606 ISO Abbreviation: Dev. Biol. Publication Date: 2003 Aug |
Date Detail:
|
Created Date: 2003-07-29 Completed Date: 2003-09-24 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0372762 Medline TA: Dev Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 260-72 Citation Subset: IM |
Affiliation:
|
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alleles Animals Carrier Proteins / chemistry, genetics, metabolism, physiology* Cell Movement Contractile Proteins / chemistry, genetics, metabolism, physiology* Drosophila / cytology, genetics, physiology* Female Insect Proteins / chemistry, genetics, metabolism, physiology* Microfilament Proteins / chemistry, genetics, metabolism, physiology* Morphogenesis Oogenesis / physiology* Ovarian Follicle / cytology Point Mutation Protein Structure, Tertiary Transgenes |
| Grant Support | |
ID/Acronym/Agency:
|
GM57207/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Carrier Proteins; 0/Contractile Proteins; 0/Insect Proteins; 0/Microfilament Proteins; 0/filamins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: MEI-1/katanin is required for translocation of the meiosis I spindle to the oocyte cortex in C elega...
Next Document: Essential embryonic roles of the CKI-1 cyclin-dependent kinase inhibitor in cell-cycle exit and morp...