| Drosophila fasciclin I, a neural cell adhesion molecule, has a phosphatidylinositol lipid membrane anchor that is developmentally regulated. | |
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MedLine Citation:
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PMID: 2394715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fasciclin I is a homophilic neural cell adhesion molecule which is regionally expressed on a subset of fasciculating axons in both the grasshopper and Drosophila embryo, suggesting a role in axonal recognition. It is also dynamically expressed on a variety of other embryonic tissues. Biochemical analysis of the fasciclin I glycoprotein from Drosophila embryonic membranes and Schneider 1 cells indicates that it is tightly associated with the lipid bilayer by a phosphatidylinositol lipid moiety. In Drosophila embryos a large fraction of fasciclin I protein has lost its membrane anchor. The ratio of this soluble form to the phosphatidylinositol-linked form changes during embryogenesis. We speculate that removal of the phosphatidylinositol lipid from the fasciclin I protein could be a mechanism to regulate its adhesive function. |
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Authors:
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M Hortsch; C S Goodman |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of biological chemistry Volume: 265 ISSN: 0021-9258 ISO Abbreviation: J. Biol. Chem. Publication Date: 1990 Sep |
Date Detail:
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Created Date: 1990-10-09 Completed Date: 1990-10-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 15104-9 Citation Subset: IM |
Affiliation:
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Howard Hughes Medical Institute, University of California, Berkeley 94720. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Antibodies, Monoclonal / diagnostic use Cell Adhesion Molecules, Neuronal / genetics*, isolation & purification, metabolism Cells, Cultured Drosophila / embryology*, genetics Embryo, Nonmammalian / physiology Glycosylphosphatidylinositols Grasshoppers / genetics Molecular Sequence Data Phosphatidylinositols / metabolism* Polysaccharides / metabolism* Sequence Homology, Nucleic Acid |
| Grant Support | |
ID/Acronym/Agency:
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HD21294/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Cell Adhesion Molecules, Neuronal; 0/Glycosylphosphatidylinositols; 0/Phosphatidylinositols; 0/Polysaccharides; 0/fasciclin I |
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