Document Detail

Drosophila dosage compensation: males are from Mars, females are from Venus.
MedLine Citation:
PMID:  21339706     Owner:  NLM     Status:  MEDLINE    
Dosage compensation of X-linked genes is a phenomenon of concerted, chromosome-wide regulation of gene expression underpinned by sustained and tightly regulated histone modifications and chromatin remodeling, coupled with constrains of nuclear architecture. This elaborate process allows the accomplishment of regulated expression of genes on the single male X chromosome to levels comparable to those expressed from the two X chromosomes in females. The ribonucleoprotein Male Specific Lethal (MSL) complex is enriched on the male X chromosome and is intricately involved in this process in Drosophila melanogaster. In this review we discuss the recent advances that highlight the complexity lying behind regulation of gene expression by just two-fold.
Plamen Georgiev; Sarantis Chlamydas; Asifa Akhtar
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-04-01
Journal Detail:
Title:  Fly     Volume:  5     ISSN:  1933-6942     ISO Abbreviation:  Fly (Austin)     Publication Date:    2011 Apr-Jun
Date Detail:
Created Date:  2011-05-11     Completed Date:  2011-09-02     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101470897     Medline TA:  Fly (Austin)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  147-54     Citation Subset:  IM    
Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
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MeSH Terms
Chromatin Assembly and Disassembly
Chromosomes, Insect*
Dosage Compensation, Genetic*
Drosophila melanogaster / genetics*
Histones / metabolism
X Chromosome*
Reg. No./Substance:

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