Document Detail

Drosophila cell fusion induced by wheat germ agglutinin.
MedLine Citation:
PMID:  1141389     Owner:  NLM     Status:  MEDLINE    
The effects of wheat germ agglutinin on Drosophila embryonic cell lines growing on cover-glasses was examined by scanning electron microscopy. At low concentrations of the lectin (5-10 mug/ml), cells spread against the glass surface and fused to form syncytia. At high concentration, damage to the cell surface was evidenced as extensive membrane shrivelling and loss of surface microfilaments. Fusion also occurred under these conditions. There was some indication that the morphology of cells in division remains undisturbed by wheat germ agglutinin. The coalescence of cells and morphologic disotrtion induced by wheat germ agglutinin were not inhibited by N-acetylglucosamine, the hapten inhibitor of the lectin, under the conditions utilized in this study.
R M Rizki; T M Rizki; C A Andrews
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cell science     Volume:  18     ISSN:  0021-9533     ISO Abbreviation:  J. Cell. Sci.     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1975-10-10     Completed Date:  1975-10-10     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0052457     Medline TA:  J Cell Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  113-21     Citation Subset:  IM    
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MeSH Terms
Cell Differentiation
Cell Division*
Cell Fusion*
Cell Line
Cell Membrane / ultrastructure
Drosophila / cytology*,  embryology,  ultrastructure
Glucosamine / analogs & derivatives
Lectins / adverse effects*,  analysis,  antagonists & inhibitors
Microscopy, Electron, Scanning
Plant Lectins
Triticum / embryology
Reg. No./Substance:
0/Lectins; 0/Plant Lectins; 3416-24-8/Glucosamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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