Document Detail


The Drosophila Tumorous-lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus.
MedLine Citation:
PMID:  8479437     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Drosophila Tumorous-lethal (Tum-l) mutation acts as an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation. Tum-l is a dominant mutation in the hopscotch (hop) locus, which is required for cell division and for proper embryonic segmentation. The Tum-l temperature-sensitive period for melanotic tumor formation includes most of larval and pupal development.
Authors:
W P Hanratty; C R Dearolf
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Molecular & general genetics : MGG     Volume:  238     ISSN:  0026-8925     ISO Abbreviation:  Mol. Gen. Genet.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-05-26     Completed Date:  1993-05-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0125036     Medline TA:  Mol Gen Genet     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  33-7     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, University of Southern Mississippi, Hattiesburg 39406.
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MeSH Terms
Descriptor/Qualifier:
Animals
Crosses, Genetic
Drosophila melanogaster / genetics*
Female
Genes, Dominant*
Genes, Lethal*
Genetic Complementation Test
Male
Mutation*
Oncogenes*
Recombination, Genetic
Temperature
Time Factors
Grant Support
ID/Acronym/Agency:
CA24488/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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