| Drosophila Tracks Carbon Dioxide in Flight. | |
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MedLine Citation:
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PMID: 23352695 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Carbon dioxide (CO(2)) elicits an attractive host-seeking response from mosquitos [1-3] yet is innately aversive to Drosophila melanogaster [4, 5] despite being a plentiful byproduct of attractive fermenting food sources. Prior studies used walking flies exclusively, yet adults track distant food sources on the wing [6]. Here we show that a fly tethered within a magnetic field allowing free rotation about the yaw axis [7] actively seeks a narrow CO(2) plume during flight. Genetic disruption of the canonical CO(2)-sensing olfactory neurons does not alter in-flight attraction to CO(2); however, antennal ablation and genetic disruption of the Ir64a acid sensor do. Surprisingly, mutation of the obligate olfactory coreceptor (Orco [8]) does not abolish CO(2) aversion during walking [4] yet eliminates CO(2) tracking in flight. The biogenic amine octopamine regulates critical physiological processes during flight [9-11], and blocking synaptic output from octopamine neurons inverts the valence assigned to CO(2) and elicits an aversive response in flight. Combined, our results suggest that a novel Orco-mediated olfactory pathway that gains sensitivity to CO(2) in flight via changes in octopamine levels, along with Ir64a, quickly switches the valence of a key environmental stimulus in a behavioral-state-dependent manner. |
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Authors:
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Sara Wasserman; Alexandra Salomon; Mark A Frye |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-22 |
Journal Detail:
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Title: Current biology : CB Volume: - ISSN: 1879-0445 ISO Abbreviation: Curr. Biol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107782 Medline TA: Curr Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2013 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Integrative Biology and Physiology, Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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