Document Detail

Drosophila tracks carbon dioxide in flight.
MedLine Citation:
PMID:  23352695     Owner:  NLM     Status:  MEDLINE    
Carbon dioxide (CO(2)) elicits an attractive host-seeking response from mosquitos yet is innately aversive to Drosophila melanogaster despite being a plentiful byproduct of attractive fermenting food sources. Prior studies used walking flies exclusively, yet adults track distant food sources on the wing. Here we show that a fly tethered within a magnetic field allowing free rotation about the yaw axis actively seeks a narrow CO(2) plume during flight. Genetic disruption of the canonical CO(2)-sensing olfactory neurons does not alter in-flight attraction to CO(2); however, antennal ablation and genetic disruption of the Ir64a acid sensor do. Surprisingly, mutation of the obligate olfactory coreceptor (Orco) does not abolish CO(2) aversion during walking yet eliminates CO(2) tracking in flight. The biogenic amine octopamine regulates critical physiological processes during flight, and blocking synaptic output from octopamine neurons inverts the valence assigned to CO(2) and elicits an aversive response in flight. Combined, our results suggest that a novel Orco-mediated olfactory pathway that gains sensitivity to CO(2) in flight via changes in octopamine levels, along with Ir64a, quickly switches the valence of a key environmental stimulus in a behavioral-state-dependent manner.
Sara Wasserman; Alexandra Salomon; Mark A Frye
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-24
Journal Detail:
Title:  Current biology : CB     Volume:  23     ISSN:  1879-0445     ISO Abbreviation:  Curr. Biol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-22     Completed Date:  2013-08-06     Revised Date:  2013-11-03    
Medline Journal Info:
Nlm Unique ID:  9107782     Medline TA:  Curr Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  301-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
Department of Integrative Biology and Physiology, Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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MeSH Terms
Arthropod Antennae / physiology
Behavior, Animal / physiology*
Carbon Dioxide*
Drosophila Proteins / genetics,  metabolism
Drosophila melanogaster / metabolism,  physiology*
Flight, Animal / physiology*
Magnetic Fields
Octopamine / metabolism
Olfactory Pathways / metabolism
Receptors, Ionotropic Glutamate / genetics,  metabolism
Receptors, Odorant
Smell / physiology
Grant Support
//Howard Hughes Medical Institute; //Howard Hughes Medical Institute
Reg. No./Substance:
0/Drosophila Proteins; 0/IR64a protein, Drosophila; 0/Receptors, Ionotropic Glutamate; 0/Receptors, Odorant; 104-14-3/Octopamine; 124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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