| Drosophila and Galleria insect model hosts: New tools for the study of fungal virulence, pharmacology and immunology. | |
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MedLine Citation:
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PMID: 22186764 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Over recent years we have witnessed the emergence of several non-vertebrate mini-hosts as alternative pathosystems for the study of fungal disease. These heterologous organisms have unique advantages, as they are economical, ethically expedient, and facile to use. Hence, they are amenable to high-throughput screening studies of fungal genomes for identification of novel virulence genes and of chemical libraries for discovery of new antifungal compounds. In addition, because they have evolutionarily conserved immunity they offer the opportunity to better understand innate immune responses against medically important fungi. In this review, we discuss how the insects Drosophila melanogaster and Galleria mellonella can be employed for the study of various facets of host-fungal interactions as complementary hosts to conventional vertebrate animal models. |
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Authors:
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Michail S Lionakis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Virulence Volume: 2 ISSN: 2150-5608 ISO Abbreviation: Virulence Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101531386 Medline TA: Virulence Country: United States |
Other Details:
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Languages: eng Pagination: 521-7 Citation Subset: IM |
Affiliation:
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Clinical Mycology Unit; Laboratory of Molecular Immunology; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, MD USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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