Document Detail

Drosophila G9a is a nonessential gene.
MedLine Citation:
PMID:  18039887     Owner:  NLM     Status:  MEDLINE    
Mammalian G9a is a euchromatic histone H3 lysine 9 (H3K9) methyltransferase essential for development. Here, we characterize the Drosophila homolog of G9a, dG9a. We generated a dG9a deletion allele by homologous recombination. Analysis of this allele revealed that, in contrast to recent findings, dG9a is not required for fly viability.
Carole Seum; Séverine Bontron; Emanuela Reo; Marion Delattre; Pierre Spierer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genetics     Volume:  177     ISSN:  0016-6731     ISO Abbreviation:  Genetics     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-27     Completed Date:  2008-02-11     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1955-7     Citation Subset:  IM    
Department of Zoology and Animal Biology, University of Geneva, CH-1211 Geneva 4, Switzerland.
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MeSH Terms
Animals, Genetically Modified
Drosophila / enzymology*,  genetics*,  growth & development
Gene Deletion
Genes, Insect*
Histone-Lysine N-Methyltransferase / genetics*
Larva / enzymology,  growth & development
Protein Methyltransferases
Recombination, Genetic
Reg. No./Substance:
EC 2.1.1.-/Protein Methyltransferases; EC 2.1.1.-/histone methyltransferase; EC N-Methyltransferase

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