| Dropouts in the AB/BA crossover design. | |
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MedLine Citation:
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PMID: 22362410 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Missing data arise in crossover trials, as they do in any form of clinical trial. Several papers have addressed the problems that missing data create, although almost all of these assume that the probability that a planned observation is missing does not depend on the value that would have been observed; that is, the data are missing at random (MAR). In many applications, this assumption is likely to be untenable; in which case, the data are missing not at random (MNAR). We investigate the effect on estimates of the treatment effect that assume data are MAR when data are actually MNAR. We also propose using the assumption of no carryover treatment effect, which is usually required for this design, to permit the estimation of a treatment effect when data are MNAR. The results are applied to a trial comparing two treatments for neuropathic pain and show that the estimate of treatment effect is sensitive to the assumption of MAR. Copyright © 2012 John Wiley & Sons, Ltd. |
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Authors:
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Weang Kee Ho; John N S Matthews; Robin Henderson; Daniel Farewell; Lauren R Rodgers |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-23 |
Journal Detail:
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Title: Statistics in medicine Volume: - ISSN: 1097-0258 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8215016 Medline TA: Stat Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 John Wiley & Sons, Ltd. |
Affiliation:
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School of Mathematics and Statistics, Newcastle University, Newcastle upon Tyne, NE1 7RU, U.K. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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