Document Detail


Dronedarone: a new antiarrhythmic agent.
MedLine Citation:
PMID:  16541184     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dronedarone (SR 33589; N,N-dibutyl-3-[4-([2-butyl-5-methylsulphonamido] benzofuran-3-yl-carbonyl) phenoxy]propylamine) is a new synthetic noniodinated derivative of amiodarone that is currently undergoing phase III clinical trials. It demonstrates electrophysiologic patterns similar to amiodarone and shows equivalent efficacy in preventing or converting various ventricular and atrial arrhythmias in laboratory animals. Two phase III trials demonstrated that dronedarone is safe and effective for the maintenance of normal sinus rhythm in patients with atrial fibrillation or atrial flutter. Dronedarone at the dose of 400 mg twice daily was effective in preventing both symptomatic and asymptomatic recurrences of atrial fibrillation or atrial flutter and had a safety profile similar to that of placebo. Further studies are needed to determine the long-term effectiveness and safety of dronedarone in various groups of patients with atrial fibrillation. Other clinical applications of this novel antiarrhythmic drug need to be determined in future clinical trials.
Authors:
Karolina M Zareba
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drugs of today (Barcelona, Spain : 1998)     Volume:  42     ISSN:  1699-3993     ISO Abbreviation:  Drugs Today     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-03-16     Completed Date:  2006-05-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101160518     Medline TA:  Drugs Today (Barc)     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  75-86     Citation Subset:  IM    
Affiliation:
University of Rochester School of Medicine, Rochester, New York 14642, USA. karolina_zareba@urmc.rochester.edu
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MeSH Terms
Descriptor/Qualifier:
Amiodarone / adverse effects,  analogs & derivatives*,  pharmacology,  therapeutic use
Animals
Anti-Arrhythmia Agents* / adverse effects,  pharmacology,  therapeutic use
Atrial Fibrillation / drug therapy
Atrial Flutter / drug therapy
Biological Availability
Clinical Trials as Topic
Humans
Metabolic Clearance Rate
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/dronedarone; 1951-25-3/Amiodarone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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