| Dronedarone: a new antiarrhythmic agent. | |
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MedLine Citation:
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PMID: 16541184 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dronedarone (SR 33589; N,N-dibutyl-3-[4-([2-butyl-5-methylsulphonamido] benzofuran-3-yl-carbonyl) phenoxy]propylamine) is a new synthetic noniodinated derivative of amiodarone that is currently undergoing phase III clinical trials. It demonstrates electrophysiologic patterns similar to amiodarone and shows equivalent efficacy in preventing or converting various ventricular and atrial arrhythmias in laboratory animals. Two phase III trials demonstrated that dronedarone is safe and effective for the maintenance of normal sinus rhythm in patients with atrial fibrillation or atrial flutter. Dronedarone at the dose of 400 mg twice daily was effective in preventing both symptomatic and asymptomatic recurrences of atrial fibrillation or atrial flutter and had a safety profile similar to that of placebo. Further studies are needed to determine the long-term effectiveness and safety of dronedarone in various groups of patients with atrial fibrillation. Other clinical applications of this novel antiarrhythmic drug need to be determined in future clinical trials. |
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Authors:
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Karolina M Zareba |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Drugs of today (Barcelona, Spain : 1998) Volume: 42 ISSN: 1699-3993 ISO Abbreviation: Drugs Today Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-03-16 Completed Date: 2006-05-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101160518 Medline TA: Drugs Today (Barc) Country: Spain |
Other Details:
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Languages: eng Pagination: 75-86 Citation Subset: IM |
Affiliation:
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University of Rochester School of Medicine, Rochester, New York 14642, USA. karolina_zareba@urmc.rochester.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amiodarone
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adverse effects,
analogs & derivatives*,
pharmacology,
therapeutic use Animals Anti-Arrhythmia Agents* / adverse effects, pharmacology, therapeutic use Atrial Fibrillation / drug therapy Atrial Flutter / drug therapy Biological Availability Clinical Trials as Topic Humans Metabolic Clearance Rate Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/dronedarone; 1951-25-3/Amiodarone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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