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Dronedarone and Captisol-enabled Amiodarone in an experimental Cardiac Arrest.
MedLine Citation:
PMID:  23364604     Owner:  NLM     Status:  Publisher    
OBJECTIVE:: To compare the energy required for defibrillation and post shock outcomes following the administration of dronedarone, amiodarone and placebo in a porcine model of cardiac arrest. METHODS:: Forty-two pigs were randomised either amiodarone, dronedarone or control treatments. Following induction of ventricular fibrillation, compressions and ventilations were performed for 3 minutes and treatment was administered over 30 seconds. If defibrillation was unsuccessful, cardiopulmonary resuscitation continued and repeated shocks were administered every 2 minutes with continual haemodynamic monitoring for a total duration of 30 minutes. RESULTS:: The cumulative energy required for defibrillation was 570J ± 422 for dronedarone, 441J ± 365 for amiodarone and 347J ± 281 for control (p=ns). Survival at 30 minutes was 1 (7.1%) for dronedarone compared with 11 (78.6%) for control (p=0.001). Mortality in the dronedarone group was due to refibrillation in 3 (21.4%) cases, atrioventricular (AV) block in 1 (7.1 %) cases and hypotension not due to bradycardia in 9 (64.3%) cases.Two minutes post successful defibrillation, systolic aortic pressure was lower in dronedarone versus control (86.6±26.9 mm Hg versus 110±15.1 mm Hg; p=0.035). CONCLUSIONS:: The administration of dronedarone resulted in a significant reduction in survival and both systolic aortic and coronary perfusion pressure compared with control.
Benedict M Glover; Xudong Hu; Theresa Aves; Andrew Ramadeen; Lily Zou; Howard Leong-Poi; Hiroko Fujii; Paul Dorian
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-29
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  -     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada 2Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
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