Document Detail


Driving IL-17(+) γδ T-cell migration in allergic reactions: A new "inflammatory" role for the "homeostatic" chemokine CCL25.
MedLine Citation:
PMID:  22539284     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Chemokines are traditionally classified as homeostatic or inflammatory depending on whether they direct leukocyte migration in the absence or presence of inflammatory stimuli. CC chemokine ligand (CCL)25, a ligand for CC chemokine receptor (CCR)9, has mostly been characterized as a homeostatic chemokine that determines the migration pathway of T-cell progenitors within the thymus, and the recruitment of various lymphocyte subsets to the intestinal mucosa. In this issue of the European Journal of Immunology, Costa et al. [Eur. J. Immunol. 2012. 42: 1250-1260] describe a new inflammatory role for CCL25/CCR9 in controlling the migration of a subset of γδ Tcells committed to IL-17 production (γδ17 cells) in a model of allergic pleurisy. Interestingly, the effect of CCL25 was selective for γδ17 cells, as it did not extend to other γδ or αβ T-cell subsets, and resulted in a specific increase of IL-17 (but not IL-4 or IFN-γ) levels in the allergic pleura. In this commentary, I discuss these results in the context of chemokine-mediated recruitment of γδ Tcells to inflammatory sites, and the as yet unclear and controversial role of IL-17 in allergic reactions.
Authors:
Bruno Silva-Santos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of immunology     Volume:  42     ISSN:  1521-4141     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1097-101     Citation Subset:  IM    
Copyright Information:
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal; Instituto Gulbenkian de Ciência, Oeiras, Portugal.
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