| Drivers of oxidative stress in acute pancreatitis: the role of nutrition therapy. | |
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MedLine Citation:
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PMID: 22235106 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Severe acute pancreatitis is a disease process distinguished by increasing oxidative stress and potential destruction of the pancreatic gland. An initial injury to the acinar cell initiates a sentinel event, which leads to a vicious cycle of inflammation and cell death by either apoptosis or necrosis. Whether the acute inflammation resolves or goes on to a pattern of chronicity may be related to genetic predisposition, failure to remove injurious agents, and innate systems for antioxidant defense. The degree to which nutrition therapy can modulate oxidative stress, maintain intestinal function, and preserve the structure of the acinar cell is truly amazing. Understanding the mechanisms involved in this complex disease process and the manner in which these mechanisms are influenced by dietary agents affords new and exciting therapeutic options for the future. |
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Authors:
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Stephen A McClave |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: JPEN. Journal of parenteral and enteral nutrition Volume: 36 ISSN: 0148-6071 ISO Abbreviation: JPEN J Parenter Enteral Nutr Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804134 Medline TA: JPEN J Parenter Enteral Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 24-35 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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