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Drinking water and pregnancy outcome in central North Carolina: source, amount, and trihalomethane levels.
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MedLine Citation:
PMID:  7556013     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In spite of the recognition of potentially toxic chemicals in chlorinated drinking water, few studies have evaluated reproductive health consequences of such exposure. Using data from a case-control study of miscarriage, preterm delivery, and low birth weight in central North Carolina, we evaluated risk associated with water source, amount, and trihalomethane (THM) concentration. Water source was not related to any of those pregnancy outcomes, but an increasing amount of ingested water was associated with decreased risks of all three outcomes (odds ratios around 1.5 for 0 glasses per day relative to 1-3 glasses per day, falling to 0.8 for 4+ glasses per day). THM concentration and dose (concentration x amount) were not related to pregnancy outcome, with the possible exception of an increased risk of miscarriage in the highest sextile of THM concentration (adjusted odds ratio = 2.8, 95% confidence interval = 1.1-2.7), which was not part of an overall dose-response gradient. These data do not indicate a strong association between chlorination by-products and adverse pregnancy outcome, but given the limited quality of our exposure assessment and the increased miscarriage risk in the highest exposure group, more refined evaluation is warranted.
Authors:
D A Savitz; K W Andrews; L M Pastore
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Environmental health perspectives     Volume:  103     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-11-13     Completed Date:  1995-11-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  592-6     Citation Subset:  IM    
Affiliation:
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599, USA.
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Chlorofluorocarbons, Methane / adverse effects*
Dose-Response Relationship, Drug
Evaluation Studies as Topic
Female
Fresh Water / chemistry*
Humans
North Carolina / epidemiology
Pregnancy
Pregnancy Outcome / epidemiology*
Risk Factors
Water Pollutants, Chemical / adverse effects*
Grant Support
ID/Acronym/Agency:
HD23862/HD/NICHD NIH HHS; HD23862S/HD/NICHD NIH HHS; R48/CCR402177//PHS HHS
Chemical
Reg. No./Substance:
0/Chlorofluorocarbons, Methane; 0/Water Pollutants, Chemical
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 6 Year: 1995
Volume: 103 Issue: 6
First Page: 592 Last Page: 596
ID: 1519129
PubMed Id: 7556013

Drinking water and pregnancy outcome in central North Carolina: source, amount, and trihalomethane levels.
D A Savitz
K W Andrews
L M Pastore
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599, USA.



Article Categories:
  • Research Article


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