| Drinking water and pregnancy outcome in central North Carolina: source, amount, and trihalomethane levels. | |
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MedLine Citation:
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PMID: 7556013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In spite of the recognition of potentially toxic chemicals in chlorinated drinking water, few studies have evaluated reproductive health consequences of such exposure. Using data from a case-control study of miscarriage, preterm delivery, and low birth weight in central North Carolina, we evaluated risk associated with water source, amount, and trihalomethane (THM) concentration. Water source was not related to any of those pregnancy outcomes, but an increasing amount of ingested water was associated with decreased risks of all three outcomes (odds ratios around 1.5 for 0 glasses per day relative to 1-3 glasses per day, falling to 0.8 for 4+ glasses per day). THM concentration and dose (concentration x amount) were not related to pregnancy outcome, with the possible exception of an increased risk of miscarriage in the highest sextile of THM concentration (adjusted odds ratio = 2.8, 95% confidence interval = 1.1-2.7), which was not part of an overall dose-response gradient. These data do not indicate a strong association between chlorination by-products and adverse pregnancy outcome, but given the limited quality of our exposure assessment and the increased miscarriage risk in the highest exposure group, more refined evaluation is warranted. |
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Authors:
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D A Savitz; K W Andrews; L M Pastore |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Environmental health perspectives Volume: 103 ISSN: 0091-6765 ISO Abbreviation: Environ. Health Perspect. Publication Date: 1995 Jun |
Date Detail:
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Created Date: 1995-11-13 Completed Date: 1995-11-13 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0330411 Medline TA: Environ Health Perspect Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 592-6 Citation Subset: IM |
Affiliation:
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Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Chlorofluorocarbons, Methane / adverse effects* Dose-Response Relationship, Drug Evaluation Studies as Topic Female Fresh Water / chemistry* Humans North Carolina / epidemiology Pregnancy Pregnancy Outcome / epidemiology* Risk Factors Water Pollutants, Chemical / adverse effects* |
| Grant Support | |
ID/Acronym/Agency:
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HD23862/HD/NICHD NIH HHS; HD23862S/HD/NICHD NIH HHS; R48/CCR402177//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Chlorofluorocarbons, Methane; 0/Water Pollutants, Chemical |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Environ Health Perspect ISSN: 0091-6765 |
Article Information Download PDF  Print publication date: Month: 6 Year: 1995 Volume: 103 Issue: 6 First Page: 592 Last Page: 596 ID: 1519129 PubMed Id: 7556013 |
| Drinking water and pregnancy outcome in central North Carolina: source, amount, and trihalomethane levels. | |
| D A Savitz | |
| K W Andrews | |
| L M Pastore | |
| Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599, USA. |
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