| Drinking water disinfection by-products and time to pregnancy. | |
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MedLine Citation:
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PMID: 18379423 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Laboratory evidence suggests tap water disinfection by-products (DBPs) could have an effect very early in pregnancy, typically before clinical detectability. Undetected early losses would be expected to increase the reported number of cycles to clinical pregnancy. METHODS: We investigated the association between specific DBPs (trihalomethanes, haloacetic acids, brominated-trihalomethanes, brominated-haloacetic acids, total organic halides, and bromodichloromethane) and time to pregnancy among women who enrolled in a study of drinking water and reproductive outcomes. We quantified exposure to DBPs through concentrations in tap water, quantity ingested through drinking, quantity inhaled or absorbed while showering or bathing, and total integrated exposure. The effect of DBPs on time to pregnancy was estimated using a discrete time hazard model. RESULTS: Overall, we found no evidence of an increased time to pregnancy among women who were exposed to higher levels of DBPs. A modestly decreased time to pregnancy (ie, increased fecundability) was seen among those exposed to the highest level of ingested DBPs, but not for tap water concentration, the amount absorbed while showering or bathing, or the integrated exposure. CONCLUSIONS: Our findings extend those of a recently published study suggesting a lack of association between DBPs and pregnancy loss. |
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Authors:
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Richard F MacLehose; David A Savitz; Amy H Herring; Katherine E Hartmann; Philip C Singer; Howard S Weinberg |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Epidemiology (Cambridge, Mass.) Volume: 19 ISSN: 1044-3983 ISO Abbreviation: Epidemiology Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-17 Completed Date: 2008-07-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9009644 Medline TA: Epidemiology Country: United States |
Other Details:
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Languages: eng Pagination: 451-8 Citation Subset: IM |
Affiliation:
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Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709-2233, USA. maclehoser@niehs.ni.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Data Interpretation, Statistical Disinfectants / adverse effects* Environmental Exposure / adverse effects, analysis Female Humans Hydrocarbons, Halogenated / adverse effects, analysis Pregnancy* Prospective Studies Questionnaires Risk Factors Time Factors Trihalomethanes / adverse effects, analysis United States / epidemiology Water Pollutants, Chemical / adverse effects*, analysis Water Purification / methods* Water Supply / analysis* |
| Grant Support | |
ID/Acronym/Agency:
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P30ES10126/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Disinfectants; 0/Hydrocarbons, Halogenated; 0/Trihalomethanes; 0/Water Pollutants, Chemical |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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