Document Detail

Drinking water and dietary sources of nitrate and nitrite and risk of glioma.
MedLine Citation:
PMID:  16340707     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Dietary nitrite has been associated with increased glioma risk; however, drinking water nitrate has not been extensively evaluated. METHODS: We conducted a population-based case-control study of adult glioma in Nebraska. Water utility nitrate measurements were linked to residential water source histories. We computed average nitrate exposure over a 20-year period. A food frequency questionnaire was used to assess dietary nitrate and nitrite. RESULTS: Increasing quartiles of the average nitrate level in drinking water were not significantly associated with risk (adjusted odd ratios: 1.4, 1.2, 1.3). Risk was similar among those with both higher and lower intakes of vitamin C, an inhibitor of N-nitroso compound formation. Dietary nitrite intake was not associated with risk. CONCLUSIONS: Our study does not support a role for drinking water and dietary sources of nitrate and nitrite in risk of adult glioma.
Mary H Ward; Ellen F Heineman; Rodney D McComb; Dennis D Weisenburger
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine     Volume:  47     ISSN:  1076-2752     ISO Abbreviation:  J. Occup. Environ. Med.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-03-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9504688     Medline TA:  J Occup Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1260-7     Citation Subset:  IM    
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland 20892-7240, USA.
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MeSH Terms
Aged, 80 and over
Brain Neoplasms / etiology*
Case-Control Studies
Glioma / etiology*
Middle Aged
Nitrates / analysis*
Nitrites / analysis*
Risk Assessment
Water Supply*
Reg. No./Substance:
0/Nitrates; 0/Nitrites

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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