| Drinking a hot blood meal elicits a protective heat shock response in mosquitoes. | |
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MedLine Citation:
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PMID: 21518875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mosquito's body temperature increases dramatically when it takes a blood meal from a warm-blooded, vertebrate host. By using the yellow fever mosquito, Aedes aegypti, we demonstrate that this boost in temperature following a blood meal prompts the synthesis of heat shock protein 70 (Hsp70). This response, elicited by the temperature of the blood meal, is most robust in the mosquito's midgut. When RNA interference is used to suppress expression of hsp70, protein digestion of the blood meal is impaired, leading to production of fewer eggs. We propose that Hsp70 protects the mosquito midgut from the temperature stress incurred by drinking a hot blood meal. Similar increases in hsp70 were documented immediately after blood feeding in two other mosquitoes (Culex pipiens and Anopheles gambiae) and the bed bug, Cimex lectularius, suggesting that this is a common protective response in blood-feeding arthropods. |
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Authors:
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Joshua B Benoit; Giancarlo Lopez-Martinez; Kevin R Patrick; Zachary P Phillips; Tyler B Krause; David L Denlinger |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2011-04-25 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 108 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-11 Completed Date: 2011-07-15 Revised Date: 2011-11-10 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 8026-9 Citation Subset: IM |
Affiliation:
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Department of Entomology and Evolution, Ecology and Organismal Biology, The Ohio State University, Columbus, OH 43210, USA. joshua.benoit@yale.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aedes
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genetics,
physiology Animals Anopheles gambiae / genetics, physiology Bedbugs / genetics, physiology Blood Body Temperature / physiology Culex / genetics, physiology Culicidae / genetics, physiology* Female HSP70 Heat-Shock Proteins / antagonists & inhibitors, biosynthesis, genetics Heat-Shock Response / genetics, physiology* Hot Temperature Insect Proteins / antagonists & inhibitors, biosynthesis, genetics RNA Interference |
| Grant Support | |
ID/Acronym/Agency:
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R01AI058279/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/HSP70 Heat-Shock Proteins; 0/Insect Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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