| Drinking and driving pancreatitis: Links between endoplasmic reticulum stress and autophagy. | |
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MedLine Citation:
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PMID: 21460613 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Alcohol abuse is the leading etiologic factor of pancreatitis, although many heavy drinkers do not develop pancreatic damage. Alcohol promotes pancreatitis through a combination of remote (e.g., increased gut permeability to bacterial products such as lipopolysaccharide) and more proximal effects (e.g., altered pancreatic cholinergic inputs), including oxidative damage at the level of the pancreatic acinar cell. Recent evidence indicates that alcohol exposure to rodents disturbs proteostasis in the exocrine pancreas, an effect counterbalanced by homeostatic processes that include both the unfolded protein response (UPR) and autophagy. A corollary to this notion is that pancreatitis results when adaptive responses are insufficiently robust to alleviate the cellular stress caused by alcohol. |
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Authors:
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Aurelia Lugea; Richard T Waldron; Samuel W French; Stephen J Pandol |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-01 |
Journal Detail:
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Title: Autophagy Volume: 7 ISSN: 1554-8635 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-4-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101265188 Medline TA: Autophagy Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Southern California Research Center for ALPD & Cirrhosis; VA Greater Los Angeles Healthcare System and University of California, Los Angeles; Los Angeles, CA USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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