| Drinking and arterial blood pressure responses to ANG II in young and old rats. | |
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MedLine Citation:
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PMID: 20739604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated water drinking and arterial blood pressure responses to intravenous infusions of ANG II in young (4 mo), middle-aged adult (12 mo), and old (29 mo) male Brown Norway rats. Infusions of ANG II began with arterial blood pressure either at control levels or at reduced levels following injection of the vasodilator minoxidil. Under control conditions, mean arterial pressure (MAP) in response to ANG II rose to the same level for all groups, and middle-aged and old rats drank as much or more water in response to ANG II compared with young rats, depending on whether intakes were analyzed using absolute or body weight-adjusted values. When arterial blood pressure first was reduced with minoxidil, MAP in response to ANG II stabilized at significantly lower levels compared with control conditions for all groups. Young rats drank significantly more water under reduced pressure conditions compared with control conditions, while middle-aged and old rats did not. Urine volume in response to ANG II was lower, while water balance was higher, under conditions of reduced pressure compared with control conditions. Baroreflex control of heart rate was substantially reduced in old rats compared with young and middle-aged animals. In summary, young rats appear to be more sensitive to the inhibitory effects of increased arterial blood pressure on water drinking than are older animals. |
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Authors:
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Robert L Thunhorst; Terry G Beltz; Alan Kim Johnson |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2010-08-25 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 299 ISSN: 1522-1490 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-03 Completed Date: 2010-12-01 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R1135-41 Citation Subset: IM |
Affiliation:
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Dept. of Psychology, Univ. of Iowa, 11 Seashore Hall E., Iowa City, IA 52242-1407, USA. robert-thunhorst@uiowa.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Age Factors Aging* Angiotensin I / administration & dosage Angiotensin II / administration & dosage* Angiotensin-Converting Enzyme Inhibitors / administration & dosage Animals Baroreflex / drug effects Behavior, Animal / drug effects* Blood Pressure / drug effects* Captopril / administration & dosage Dose-Response Relationship, Drug Drinking / drug effects* Drinking Behavior / drug effects* Heart Rate / drug effects Infusions, Intravenous Male Minoxidil / administration & dosage Rats Rats, Inbred BN Rats, Sprague-Dawley Urodynamics / drug effects Vasodilator Agents / administration & dosage Water-Electrolyte Balance / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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AG-25465/AG/NIA NIH HHS; DK-66086/DK/NIDDK NIH HHS; HL-14388/HL/NHLBI NIH HHS; HL-57472/HL/NHLBI NIH HHS; MH-59239/MH/NIMH NIH HHS; R01 HL098207-02/HL/NHLBI NIH HHS; R01 MH080241-03/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Vasodilator Agents; 11128-99-7/Angiotensin II; 38304-91-5/Minoxidil; 62571-86-2/Captopril; 9041-90-1/Angiotensin I |
| Comments/Corrections | |
Comment In:
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Am J Physiol Regul Integr Comp Physiol. 2010 Nov;299(5):R1133-4
[PMID:
20702805
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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