Document Detail

Drimane-type Sesquiterpenes with a Dioxabicyclooctane Skeleton from the Fruiting Bodies of Nigrofomes melanoporus and Their Cytotoxicity.
MedLine Citation:
PMID:  22437245     Owner:  NLM     Status:  Publisher    
Two new drimane-type compounds, nigrofomins A ( 1) and B ( 2), possessing a rare dioxabicyclooctane moiety, were purified from the fruiting bodies of NIGROFOMES MELANOPORUS. Their structures were determined using 1D-, 2D-NMR and HR-ESI-MS spectroscopic analyses. In addition, 1 was established by X-ray crystallographic studies. Both nigrofomins A ( 1) and B ( 2) exhibited cytotoxicity on acute T-cell leukemia (Jurkat), human nasopharyngeal carcinoma (NPC-TW01), and lung cancer (NCI-H661) cells with IC (50) values in the range of 99.44-246.32 µM. Furthermore, the effects of 1 and 2 on cell-cycle progression of Jurkat cells displayed a concentration-dependent accumulation in the G (0)/G (1) phase.
Hsiu-Hui Chan; Shin-Hun Juang; Tran Dinh Thang; Min-Yu Chen; Ping-Chung Kuo; Mei-Lin Yang; Nguyen Thi Ngan; Nguyen Ngoc Linh; Tian-Shung Wu
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Publication Detail:
Type:  LETTER     Date:  2012-3-21
Journal Detail:
Title:  Planta medica     Volume:  -     ISSN:  1439-0221     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, Taiwan.
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