| Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula. | |
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MedLine Citation:
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PMID: 19778087 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seven new drimane sesquiterpenoids (1-3, 6-9), along with the known compounds deoxyuvidin B (4), strobilactone B (5), and RES-1149-2 (10), were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine sponge Suberites domuncula. Their structures were established by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS. Compounds 6, 7, and 10 showed cytotoxic activity against a panel of tumor cell lines, including L5178Y, HeLa, and PC12 cells, with 7 being the most active (EC(50) against L5178Y cell line: 0.6 microg/mL). |
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Authors:
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Hongbing Liu; RuAngelie Edrada-Ebel; Rainer Ebel; Yao Wang; Barbara Schulz; Siegfried Draeger; Werner E G Müller; Victor Wray; Wenhan Lin; Peter Proksch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of natural products Volume: 72 ISSN: 1520-6025 ISO Abbreviation: J. Nat. Prod. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-25 Completed Date: 2009-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
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Languages: eng Pagination: 1585-8 Citation Subset: IM |
Affiliation:
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Institut fur Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universitat Dusseldorf, Universitatsstrasse 1, Dusseldorf, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / chemistry, isolation & purification*, pharmacology Aspergillus / chemistry* Drug Screening Assays, Antitumor Hela Cells Humans Marine Biology Molecular Structure Sesquiterpenes / chemistry, isolation & purification*, pharmacology Suberites / microbiology |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Sesquiterpenes; 0/drimane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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