Document Detail


Dramatic response to levamisole and low-dose prednisolone in 23 patients with oral lichen planus: a 6-year prospective follow-up study.
MedLine Citation:
PMID:  8680979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this prospective study was to evaluate the short-term and long-term clinical efficacy of levamisole used with low-dose prednisolone in patients with refractory oral lichen planus. Twenty-three patients with OLP who had been treated unsuccessfully with other modalities were given 150 mg/day levamisole and 15 mg/day prednisolone for 3 consecutive days each week. Twelve patients showed dramatic remission of signs and symptoms within 2 weeks, whereas 11 had partial remission. All 23 reported significant pain relief and showed no evidence of erosive oral lichen planus after 4 to 6 weeks of treatment. All 23 also remained free from symptoms for 6 to 9 months after the treatment ended. There were few side effects from this treatment besides minor skin rash, headache, and insomnia from the levamisole in three cases. We conclude that the addition of levamisole to prednisolone may produce improved results in the management of erosive oral lichen planus.
Authors:
S Y Lu; W J Chen; H L Eng
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics     Volume:  80     ISSN:  1079-2104     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-08-19     Completed Date:  1996-08-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9508562     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  705-9     Citation Subset:  D; IM    
Affiliation:
Department of Dentistry, Ghang Gung Memorial Hospital, Kaohsiung, Taiwan, Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Aged
Anti-Inflammatory Agents / administration & dosage*,  therapeutic use
Drug Therapy, Combination
Female
Follow-Up Studies
Humans
Immunologic Factors / administration & dosage*,  therapeutic use
Levamisole / administration & dosage*,  therapeutic use
Lichen Planus, Oral / drug therapy*
Male
Middle Aged
Prednisolone / administration & dosage*,  therapeutic use
Prospective Studies
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Immunologic Factors; 14769-73-4/Levamisole; 50-24-8/Prednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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